复方丹参注射液联合奥拉西坦对血管性痴呆患者中医证候及炎症因子的影响

Influence of Compound Danshen Injection combined with oxiracetam on TCM syndrome and inflammatory factor in treatment of vascular dementia

目的探讨复方丹参注射液联合奥拉西坦对血管性痴呆患者中医证候及炎症因子的影响。方法对南阳市精神病医院2016年1月—2017年12月63例血管性痴呆患者的临床资料进行回顾性研究,根据不同的给药方案将其分为对照组31例和观察组32例,对照组患者给予奥拉西坦治疗,观察组患者在对照组的基础上联合复方丹参注射液治疗,均持续治疗1个月。比较两组患者的临床疗效、治疗前后的中医证候、认知功能、日常生活自理能力及血清炎性因子水平变化。结果观察组患者治疗总有效率为96.38%,对照组患者治疗总有效率为80.65%,两组比较差异显著(P<0.05)。治疗后两组患者各中医证候评分较治疗前均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组优于对照组,两组比较差异显著(P<0.05)。治疗后两组MMSE及ADL评分较治疗前均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组优于对照组,两组比较差异显著(P<0.05)。治疗后两组患者各炎症因子水平较治疗前均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组优于对照组,两组比较差异显著(P<0.05)。结论复方丹参注射液联合奥拉西坦可有效改善患者的中医证候及认知功能,抑制机体炎症反应,提高日常生活自理能力,疗效确切,在血管性痴呆的治疗中具有重要应用意义。

Objective To explore influence of compound danshen injection combined with oxiracetam on TCM syndrome and inflammatory factor in the treatment of vascular dementia.Methods The clinical data of 63 patients with vascular dementia were retrospectively studied from January 2016 to December 2017.According to different dosing regimens,all patients were divided into control group of 31 cases and study group of 32 cases.The study group was treated with oxiracetam,the experimental group on the basis of this combination of compound danshen injection.The clinical effect,TCM syndrome,cognitive function,self-care ability of daily life and serum inflammatory factor level changing before and after treatment between two groups were compared.Results The total effective rate in the experimental group were significant higher than in the control group(96.38%vs 80.65%)(P<0.05).After treatment,TCM syndrome score,MMSE score,ADLscore and inflammatory factor level of the two groups were significantly reduced than before treatment(P<0.05),and the experimental group were obviously better than the control group,and there was significant difference(P<0.05).Conclusions Compound danshen injection combined with oxiracetam in the treatment of vascular dementia can effectively improve on TCM syndrome and cognitive function,inhibit the body inflammatory response,increase selfcare ability of daily life,the exact effect,which has improtant value.