复方丹参注射液辅助甲氨蝶呤治疗宫外孕的临床疗效分析

Analysis of clinical efficacy of Fufang Danshen Injection in treatment of ectopic pregnancy with methotrexate

目的探讨复方丹参注射液辅助甲氨蝶呤治疗宫外孕的临床疗效。方法选取2015年3月—2017年3月在平煤神马医疗集团总医院诊治的宫外孕患者61例,根据随机数字表法将患者分为两组,对照组(30例)采用超声引导下甲氨蝶呤介入治疗,观察组(31例)在对照组的基础上给予复方丹参注射液。比较两组患者的临床疗效、临床症状恢复时间、激素水平及不良反应发生率。结果观察组总有效率为93.55%,显著高于对照组的73.33%(P<0.05);观察组患者的腹痛消失时间、1周后包块大小、人绒毛膜促性腺激素(β-HCG)恢复正常时间和阴道出血消失时间均显著小于对照组(P<0.05)。两组患者治疗后雌激素(E2)、孕酮(P)和睾酮(T)水平均显著下降(P<0.05),但组间比较均无统计学差异。两组总不良反应发生率无统计学差异,均经对症处理后好转。结论复方丹参注射液辅助甲氨蝶呤介入治疗宫外孕临床效果显著,可快速解除临床症状,提高治疗有效率,且不影响患者的激素水平,不增加不良反应发生率,值得临床借鉴。

Objective To explore the clinical efficacy of Fufang Danshen Injection in the treatment of ectopic pregnancy with methotrexate.Methods 61 cases of ectopic pregnancy diagnosed and treated in our hospital from March 2015 to March 2017 were selected,and were divided into two groups.The control group(30 cases)was interventional treatment with methotrexate guided by ultrasound,and the observation group(31 cases)was given Fufang Danshen Injection on the basis of the control group.Clinical efficacy,recovery time of clinical symptoms,hormone level and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).In the observation group,the time of abdominal pain disappearance,the mass size after 1 week,the time of the normal recovery ofβ-HCG and the time of vaginal bleeding disappearance were all lower than the control group(P<0.05).After treatment,the levels of E2,P and T were significantly decreased in both groups(P<0.05),but there was no significant difference between the two groups before and after treatment.The total incidence of adverse reactions was no significant difference between the two groups,and all of them were improved by symptomatic treatment.Conclusion The clinical effect of Fufang Danshen Injection and interventional treatment of ectopic pregnancy with methotrexate is remarkable,which can quickly relieve the clinical symptoms and improve the treatment efficiency without affecting the hormone level of the patients and without increasing the incidence of adverse reactions.It is worthy of clinical reference.