血必净联合多巴胺、酚妥拉明对慢性阻塞性肺疾病急性加重期合并多脏器功能衰竭患者预后的影响

Effect of Xuebijing combined with dopamine and phentolamine on prognosis of patients with acute exacerbation of COPD and multiple organ failure

目的探讨血必净联合多巴胺、酚妥拉明对慢性阻塞性肺疾病(COPD)急性加重期合并多脏器功能衰竭患者预后的影响。方法选取2015年6月—2018年6月安阳市第二人民医院80例COPD急性加重期并多脏器功能衰竭患者为研究对象,根据不同给药方法将入选者分为对照组和观察组,每组40例,对照组给予多巴胺+酚妥拉明,观察组在对照组基础上给予血必净注射液,连续治疗2周。比较两组患者的治疗总有效率,治疗前后各血气指标、凝血功能指标及炎症因子水平变化。结果观察组治疗总有效率(92.50%)显著高于对照组(77.50%),差异有统计学意义(P<0.05)。治疗后两组患者各血气指标及凝血功能指标较治疗前均明显改善,同组治疗前后比较差异有统计学意义(P<0.05);且观察组显著优于对照组,组间差异有统计学意义(P<0.05)。治疗后两组患者各炎症因子水平较治疗前均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组低于对照组,组间差异有统计学意义(P<0.05)。结论血必净联合多巴胺、酚妥拉明可有效改善患者的血气指标及凝血功能指标,抑制机体炎性反应,降低病死率,值得在COPD急性加重期并多脏器功能衰竭患者的治疗中应用推广。

Objective To explore effect of Xuebijing combined with dopamine and phentolamine on prognosis of patients with acute exacerbation of COPD and multiple organ failure.Methods 80 patients with acute exacerbation of COPD and multiple organ failure were selected as the subjects from June 2015 to June 2018.According to different administration methods,all patients were divided into control group(dopamine+phentolamine)and study group(dopamine+phentolamine+Xuebijing)with 40 cases in each group.Total treatment efficiency,blood gas index,coagulation function index and inflammatory factor level changes before and after treatment were compared the two groups.Results The total effective rate in the study group was significantly higher than that in the control group(P<0.05).After treatment,the gas and blood and coagulation function indexes in the two groups were significantly reduced than those before treatment,and the study group was significantly better than the control group(P<0.05).After treatment,the levels of inflammatory factors in both groups were significantly reduced than before treatment,and the study group was significantly lower than the control group(P<0.05).Conclusion Xuebijing combined with dopamine and phentolamine can effectively improve the gas and blood and coagulation function indexes,inhibit the body’s inflammatory response,and Reduce mortality,which has worthy of application promotion in patients with acute exacerbation of COPD and multiple organ failure.