甲氧氯普胺联合三联疗法对消化性溃疡患者微炎症状态和免疫功能的影响

Effects of methoxyclopramide combined with triple therapy on microinflammatory state and immune function in patients with peptic ulcer

目的探讨甲氧氯普胺辅助治疗消化性溃疡(PU)患者对微炎症状态、免疫功能的影响。方法采用平行、对照、回顾性研究方法,研究时间为2016年8月—2018年2月,选择在周口市中心医院诊治的PU患者124例,根据治疗方法的不同分为观察组与对照组各62例,对照组给予三联疗法治疗,观察组在对照组治疗的基础上给予甲氧氯普胺治疗,两组疗程都为14 d。结果治疗后,观察组的总有效率为98.4%,显著高于对照组的88.7%(P<0.05);观察组Hp清除率为90.3%,显著高于对照组的69.4%(P<0.05)。治疗后两组的IL-6、TNF-α水平都显著低于治疗前,同组治疗前后比较差异有统计学意义(P<0.05);且观察组也低于对照组,组间差异有统计学意义(P<0.05)。治疗后,两组CD4+显著增加,CD8+显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组变化优于对照组,组间差异有统计学意义(P<0.05);CD3+组间与组内对比差异不显著。结论甲氧氯普胺辅助治疗PU患者能抑制机体的微炎症状态,提高免疫功能,增加Hp清除率,从而提高治疗效果。

Objective To investigate the effects of metoclopramide on the micro inflammatory state and immune function in patients with peptic ulcer(PU).Methods From August 2016 to February 2018,used a parallel,controlled and retrospective study,124 cases of PU patients were selected in our hospital and were divided into the observation group and the control group of 62 patients in each groups accorded to the different treatment methods.The control group were treated with triple therapy,and the observation group were given methoxychloropp on the basis of the control group.The two group of observation times were 14 d.Results The total effective rates of the observation group was 98.4%and significantly higher than in control group(88.7%)(P<0.05);the Hp clearance rates in the observation group was 90.3%and significantly higher than in the control group(69.4%)(P<0.05).After treatment,the serum IL-6 and TNF-αof the observation group and the control group were significantly lower than those before treatment(P<0.05),and the observation group were also lower than that of the control group(P<0.05).After treatment,the CD4+of the two groups were increased significantly,and the CD8+were decreased significantly,the difference compared between the observation group and the control group were also statistically significant(P<0.05).There were no significant difference compared between the two groups before and after the treatment.Conclusion The metoclopramide in the treatment of PU patients can inhibit the micro inflammatory state,improve the immune function and increase the clearance rate of Hp,thereby improve the therapeutic effect.