天麻素注射液联合前列地尔对腔隙性脑梗死患者的临床疗效及血脂、血液流变学指标的影响

Effect of Gastrodin Injection combined with alprostadil on clinical efficacy,blood lipid and hemorheology in patients with lacunar infarction

目的探讨天麻素注射液联合前列地尔注射液对腔隙性脑梗死患者的疗效及血脂、血液流变学的影响。方法选取2015年10月—2017年12月连云港市赣榆区人民医院收治的腔隙性脑梗死患者90例作为研究对象,根据入院顺序随机分为观察组和对照组,每组各45例。对照组在常规治疗基础上,给予前列地尔注射液10μg加入100 mL生理盐水中静脉滴注,1次/d。观察组在对照组的基础上给予天麻素注射液400 mg加入250 mL生理盐水中静脉滴注,1次/d。两组均连续治疗2周。观察两组的临床疗效,同时比较两组治疗前后的血脂和血液流变学指标水平。结果治疗后,观察组治疗总有效率为91.11%,显著高于对照组的73.33%,两组比较差异有统计学意义(P<0.05)。治疗后,两组三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组明显低于对照组,两组比较差异有统计学意义(P<0.05);治疗后,观察组HDL-C水平明显升高,同组治疗前后比较差异有统计学意义(P<0.05),但两组间比较无显著差异。治疗前,两组血液流变学指标无显著差异;治疗后,两组全血黏度高切变率、全血黏度低切变率、血浆黏度、红细胞比容和红细胞聚集指数均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组明显低于对照组,差异有统计学意义(P<0.05)。结论天麻素注射液联合前列地尔注射液治疗腔隙性脑梗死可有效改善患者的血脂水平和血液流变学指标,疗效显著,优于单用前列地尔治疗。

Objective To investigate the clinical effects of Gastrodin Injection combined with Alprostadil Injection on patients with lacunar infarction and the effects of blood lipids and hemorheology.Methods 90 patients with lacunar infarction in Ganyu District People’s Hospital of Lianyungang City from October 2015 to December 2017 were randomly divided into observation group and control group according to the order of admission,each group had 45 cases.On the basis of routine treatment,the control group was given Alprostadil Injection 10μg added into 100 mL saline intravenous drip,once a day.Observation group were iv administered with Gastrodin Injection on the basis of control group,400 mg added into 250 mL saline,once daily.Patients in two groups were treated for 2 weeks.After treatment,the clinical efficacy was evaluated,and the blood lipid and hemorheology indexes levels in two groups before and after treatment were compared.Results After treatment,the total effective rate of the observation group was91.11%,which was significantly higher than 73.33%of the control group(P<0.05).After treatment,the levels of TG,TC and LDLC in the two groups were significantly decreased,and the difference was statistically significant in the same group(P<0.05).And the observation group was significantly lower than control group,with significant difference between two groups(P<0.05).After treatment,the HDL-C level of the observation group was significantly increased,and the difference was statistically significant in the same group(P<0.05),but there was no significant difference between the two groups.There was no statistically significant difference in hemorheology indexes between two groups before treatment.After treatment,high whole blood viscosity shear rate,low whole blood viscosity shear rate,plasma viscosity,erythrocyte volume,and erythrocyte aggregation index in two groups were significantly decreased,and the difference was statistically significant in the same group(P<0.05).And the hemorheology indexes in the observation group were significantly lower than those in the control group,with significant difference between two groups(P<0.05).Conclusion The combination of Gastrodin Injection combined with Alprostadil Injection in treatment of lacunar infarction can effectively improve the blood lipid level and hemorheology indexes of patients,and the curative effect is remarkable,which is better than the treatment with alprostadil alone.