丹红注射液联合尿毒清颗粒对高血压早中期慢性肾衰竭患者的尿蛋白及肾功能的影响

Effect on urinary protein and renal function in patients with hypertension included early-middle stage chronic renal failure by using Danhong Injection combined with Niaoduqing Granules

目的研究丹红注射液联合尿毒清颗粒对高血压中早期慢性肾衰竭患者的尿蛋白及肾功能的影响。方法选择2015年5月—2018年5月在宝鸡市中医医院进行诊治的83例高血压早中期慢性肾衰竭患者为研究对象,随机分为观察组(43例)对照组(40例)。对照组口服尿毒清颗粒治疗,5 g/次,4次/d;观察组在对照组基础上静脉滴注丹红注射液40 mL+5%葡萄糖注射液200 mL,1次/d。两组均治疗3周。比较两组治疗前后的临床疗效、肾功能指标和实验室指标的变化。结果治疗后观察组的总有效率为88.37%,显著高于对照组的65.00%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者的血肌酐(Scr)、尿素氮(BUN)和24 h尿蛋白量与治疗前比均降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组各项肾功能指标水平显著低于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者的β2微球蛋白(β2-MG)、血清胱抑素C(Cys-C)、内皮素1(ET-1)和超敏C反应蛋白(hs-CRP)水平与治疗前比均降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组各项实验室指标显著低于对照组,两组比较差异有统计学意义(P<0.05)。结论丹红注射液联合尿毒清颗粒治疗高血压早中期慢性肾衰竭疗效显著,能有效改善患者的肾功能状态和炎症状态,可在临床推广应用。

Objective To investigate the effect on urinary protein and renal function in patients of hypertension included earlymiddle stage chronic renal failure by using Danhong Injectioncombined with Niaoduqing Granules.Methods Selected 83 cases of patients with hypertension included early-middle stage chronic renal failure in Traditional Chinese Medical Hospital of Baoji from May 2015 to May 2018 were divided into observation group(43 cases)and control group(40 cases)randomly.The control group were po administered with Niaoduqing Granules,5 g/time,four times daily.The observation group were iv administered with Danhong Injection,40 mL added into 5%Glucose Injection 200 mL,once daily.Patients in two groups were treated for 3 weeks.Clinical effects,renal function indexes and laboratory examination indexes were compared.Results After treatment,the total effective rate of the observation group was 88.37%,which was significantly higher than 65.00%in the control group,and there was difference between two groups(P<0.05).After treatment,the levels of Scr,BUN,and 24 h urinary protein in two groups were significantly decreased,and the difference was statistically significant in the same group(P<0.05).And the renal function indexes in the observation group were significantly lower than those in the control group,with significant difference between two groups(P<0.05).After treatment,the levels ofβ2-MG,Cys-C,ET-1,and hs-CRP were significantly decreased,and the difference was statistically significant in the same group(P<0.05).And laboratory examination indexes in the observation group were significantly lower than those in the control group,with significant difference between two groups(P<0.05).Conclusion Danhong Injection combined with Niaoduqing Granules in treatment of hypertension included early-middle stage chronic renal failure has a significant effect,can effectively improve the renal function and inflammatory state of patients,and can be popularized in clinical application.