艾塞那肽治疗2型糖尿病患者的临床分析

A Clinical Analysis on Therapy of Exenatide for Type 2 Diabetic Patients

总结艾塞那肽成功治疗2型糖尿病患者的临床特点。回顾分析33例艾塞那肽治疗的2型糖尿病患者临床资料和实验室检查,对治疗前后数据进行比较分析。经艾塞那肽4个月治疗后,患者空腹血糖(FPG),2 h餐后血糖(2h PG),糖化血红蛋白(Hb Alc)均明显降低;稳态模型指数HOMA-IR,肱动脉内皮依赖性舒张功能(FMD)和体重指数(BMI)显著下降;生化指标总胆固醇(TC),低密度脂蛋白(LDL-C),谷氨酸氨基转移酶(ALT)和天门冬氨酸氨基转移酶(AST)显著下降。临床不良反应轻微。艾塞那肽治疗2型糖尿病患者,可以良好的控制血糖,减轻体重,改善胰岛素抵抗和脂质代谢紊乱。

To investigate the clinical characteristics of type 2 diabetic patients treated with exenatide,the clinical data of 33 patients who were treated with exenatide were reviewed and analyzed. After 4 months treatment of exenatide,fasting plasma glucose( FPG),2 hours postprandial plasma glucose( 2h PG),glycosylated hemoglobin( Hb Alc),homeostasis model assessment of insulin resistance index( HOMA-IR),endothelium-dependent flow-mediated vasodilation( FMD),body mass index( BMI),total cholesterol( TC),low-density lipoprotein cholesterol( LDL-C),alanine aminotransferase( ALT) and aspartate transaminase( AST) were decreased significantly. The therapy with exenatide can effectively control blood glucose,reduce weight and improve insulin resistance and disorder of lipid metabolism in type 2 diabetic patients.