新的液质联用技术在生物大分子药物中的应用进展

Progress in Novel Liquid Chromatography-Mass Spectrometry Combined Technique and its Applications in Biomacromolecule Drugs

当前已进入了21世纪第二个10年,随着联用技术的发展,生物大分子药物和基因工程药物的研究深受生化和生物医学工作者的关注。文章简要介绍了质谱法的发展,讨论了超高效色谱法的特性,综述了新的液相色谱-质谱法联用技术及其应用发展。新液质联用技术的发展及应用,为大分子类生化药物和基因工程药物的分析和鉴定开拓了广阔的前景。

Now,we are at second 10 years of 21 th century,following the development of combined techniques,the biomarcromolecule drugs and biotechnological pharmaceuticals are concerned by biochemical and biomedical workers. In this paper,the brief introduction of mass-spectrometry is introduced. The characteristic of ultraperforance chromatography is discussed. The progress on study of novel liquid chromatography-mass spectrometry combined techniques and its application is reviewed. The development of novel LC-Ms combined technique and its applications will open up broad prespects for the analysis and identification of biomacromolecule drugs and biotechnological pharmaceuticals.