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Isoniazid metabolism and hepatotoxicity 被引量：22

Isoniazid metabolism and hepatotoxicity
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摘要 Isoniazid(INH) is highly effective for the management of tuberculosis.However,it can cause liver injury and even liver failure.INH metabolism has been thought to be associated with INH-induced liver injury.This review summarized the metabolic pathways of INH and discussed their associations with INH-induced liver injury. Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury. This review summarized the metabolic pathways of INH and discussed their associations with INH-induced liver injury.
作者 Pengcheng Wang Komal Pradhan Xiao-bo Zhong Xiaochao Ma
机构地区 Center for Pharmacogenetics Department of Pharmaceutical Sciences
出处 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2016年第5期384-392,共9页 药学学报（英文版）
基金 supported in part by the U.S. National Institute of Diabetes and Digestive and Kidney Diseases (DK090305) for Xiaochao Ma the National Institute of General Medical Sciences (GM087376 and GM118367) for Xiao-bo Zhong
关键词 ISONIAZID METABOLISM HEPATOTOXICITY ANTI-TUBERCULOSIS N-ACETYLTRANSFERASE 2 AMIDASE Isoniazid Metabolism Hepatotoxicity Anti-tuberculosis N-Acetyltransferase 2 Amidase
分类号 R978.3 [医药卫生—药品]
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Acta Pharmaceutica Sinica B
2016年 第5期

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