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Insects: an underrepresented resource for the discovery of biologically active natural products 被引量:6

Insects: an underrepresented resource for the discovery of biologically active natural products
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摘要 Nature has been the source of life-changing and-saving medications for centuries. Aspirin,penicillin and morphine are prime examples of Nature's gifts to medicine. These discoveries catalyzed the field of natural product drug discovery which has mostly focused on plants. However, insects have more than twice the number of species and entomotherapy has been in practice for as long as and often in conjunction with medicinal plants and is an important alternative to modern medicine in many parts of the world. Herein, an overview of current traditional medicinal applications of insects and characterization of isolated biologically active molecules starting from approximately 2010 is presented. Insect natural products reviewed were isolated from ants, bees, wasps, beetles, cockroaches, termites, flies, true bugs,moths and more. Biological activities of these natural products from insects include antimicrobial,antifungal, antiviral, anticancer, antioxidant, anti-inflammatory and immunomodulatory effects. Nature has been the source of life-changing and -saving medications for centuries. Aspirin, penicillin and morphine are prime examples of Nature׳s gifts to medicine. These discoveries catalyzed the field of natural product drug discovery which has mostly focused on plants. However, insects have more than twice the number of species and entomotherapy has been in practice for as long as and often in conjunction with medicinal plants and is an important alternative to modern medicine in many parts of the world. Herein, an overview of current traditional medicinal applications of insects and characterization of isolated biologically active molecules starting from approximately 2010 is presented. Insect natural products reviewed were isolated from ants, bees, wasps, beetles, cockroaches, termites, flies, true bugs, moths and more. Biological activities of these natural products from insects include antimicrobial, antifungal, antiviral, anticancer, antioxidant, anti-inflammatory and immunomodulatory effects.
出处 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2017年第4期409-426,共18页 药学学报(英文版)
关键词 自然产品 昆虫 Entomotherapy 传统的药 药发现 Natural products Insects Entomotherapy Traditional medicine Drug discovery
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