2014年江苏省江阴市职业暴露人群禽流感血清学调查

Serological survey of avian influenza in occupational exposure population in Jiangyin of Jiangsu Province in 2014

目的了解江阴市职业暴露人群H5、H7、H9亚型禽流感病毒的感染状况,为制定人感染禽流感防控措施提供科学依据。方法采集监测人群血清,用马血球红细胞凝集抑制试验检测血清中的H5N1、H7N9、H9N2亚型禽流感病毒HI抗体,数据用Excel软件进行统计分析。结果共调查职业暴露人群80人,血清学结果显示14份标本H7N9和27份H9N2亚型禽流感病毒中和抗体阳性,总阳性率为45. 00%。职业暴露人群和对照组人群HI抗体效价阳性率差异有统计学意义(χ2=10. 98,P <0. 05)。问卷调查显示人群年龄偏大、文化水平偏低、流感疫苗接种率为0. 00%,防护意识较差。结论职业暴露人群存在H7N9和H9N2隐性感染现象,应加强健康教育,提高防护意识,同时加强职业人群和外环境监测,降低禽流感感染风险。

Objective To understand the infection status of avian influenza A( H5,H7 and H9) virus in occupational exposure population in Jiangyin,so as to provide scientific basis for the prevention and control of human infected avian influenza A virus( AIV). Methods The serum of the monitoring population was collected. The HI antibodies of H5 N1,H7 N9,H9 N2 subtype avian influenza virus in serum were detected with the red blood cell agglutination inhibition test. Excel software was used to analyze the results statistically. Results A total of 80 occupational exposure populations were investigated. Serological results showed that 41 out of 80 sera samples were detected positive for the neutralizing antibody of AIV( 45. 00%),which were 14 of H7 N9 subtupe and 27 of H9 N2 subtup. There was a statistically significant difference between occupational exposure and control group in AIV of H9 N2 subtype( χ2= 10. 98,P < 0. 05). Questionnaire survey showed that the exposure persons were older,the cultural level was low,the flu vaccination rate was 0. 00%,and the protection awareness was poorer. Conclusion There are infection case of AIV( H7 N9 and H9 N2 subtype) in the occupational exposure population in Jiangyin. Health education should be strengthened to improve protection awareness. At the same time,the monitoring of the occupational population and external environment should be strengthened to reduce the risk of avian influenza infection.