某HCV暴发地区非肝炎就诊人群肝炎病毒感染与暴发疫情关联分析

Correlation analysis of hepatitis virus infection and outbreak epidemic in non-hepatitis patients in a HCV outbreak area

目的对某HCV疫情暴发地区医院非肝炎就诊人群肝炎病毒感染状况及其肝功能状况进行分析,探索该人群抗-HCV阳性率与当地疫情间的关联。方法收集疫情暴发期间曾到某医院就诊的非肝炎就诊人群丙肝抗体(抗-HCV)、乙肝病毒标志物(HBV-M)及ALT等相关检测结果,并对结果进行分析。结果 164例就诊者的检测结果中,33. 5%的就诊者(55/164)抗-HCV(+),其中10. 9%的就诊者(6/55)合并HBs Ag(+); ALT结果 > 40 U/L的抗-HCV(+)就诊者占59. 2%;不同性别及年龄的就诊者HCV/HBV感染情况、ALT检测结果以及不同HBV/HCV感染状态就诊者间ALT检测结果的差异均无统计学意义(χ~2=4. 983,P=0. 079)。结论某医院就诊人群中抗-HCV阳性率与暴发疫情是否关联尚不明确,应作进一步的工作(HCV-RNA检测、流行病学资料补充等)对该地区疫情状况进行推断。

Objective To analyze the hepatitis virus infection status and liver function status of non-hepatitis patients in a HCV outbreak area,and to explore the relationship between the anti-HCV positive rate and the local epidemic.Methods Anti-HCV,HBV-M and ALT testing results of non-hepatitis patients who had visited the hospital during the outbreak were collected to analyze the situation.Results A total of 164 testing results were collected.33.5%cases were anti-HCV(+)(55/164),among those cases,6 cases(10.9%)were combined with HBs Ag(+);59.2%cases’ALT results were higher than 40 U/L;the HCV/HBV infection status and ALT testing results’difference were not significant between different gender and age cases;there were no significant difference in the ALT testing results between different HCV/HBV infection status cases(χ~2=4.983,P=0.079).Conclusion High positive rate of the hospital treatment population was undefined associated with the HCV epidemic.The HCV confirmatory testing should be taken by HCV RNA testing.