摘要
改善药物的溶解与溶出是药物制剂开发过程中面临的重要挑战。过饱和药物递送系统是近来发展的改善药物溶出和吸收的一种有效方法。综述了过饱和药物递送系统在制剂发展中的应用和形成过饱和药物递送系统过程中采用的不同类型的沉淀抑制剂及其机制,并总结了评估过饱和的体外测定方法,旨在为将难溶性药物合理设计成过饱和药物递送系统提供参考和研究思路。
Improving drug solubility and dissolution remains an important challenge in the development of pharmaceutical formulations.Supersaturating drug delivery system(SDDS)is one of the effective methods recently developed to improve drug dissolution and absorption.This paper reviewed the application of SDDS in formulation development,the different types of precipitation inhibitors used in the formation of SDDS and their mechanisms,as well as in vitro assays to evaluate supersaturation,providing reference and ideas for the rational design of SDDS for poorly water-soluble drugs.
作者
程慧
吕慧侠
CHENG Hui;LYU Huixia(School of Pharmacy,China Pharmaceutical University,Nanjing 211198,China;Department of Pharmaceutical Development Services,Shanghai SynTheAll Pharmaceuticals R&D Co.,Ltd.,Shanghai 200131,China)
出处
《药学进展》
CAS
2019年第3期181-190,共10页
Progress in Pharmaceutical Sciences
基金
国家自然科学基金资助项目(No.81673830)
关键词
过饱和药物递送系统
应用
沉淀抑制剂
抑晶机制
体外过饱和测定
supersaturating drug delivery system
application
precipitation inhibitor
crystallization inhibition mechanisms
in vitro supersaturation assays
