光动力新药帕利泊芬研究进展

Research Progress in New Photodynamic Therapy with Padeliporfin

光动力疗法被广泛用于肿瘤临床治疗,应用前景广阔。近年来的研究表明帕利泊芬是一种水溶性良好的血管靶向光敏剂,静脉给药后可选择性地聚集于肿瘤细胞内,在光激活下释放大量活性氧,从而发挥抗肿瘤疗效。该药已在欧洲获准上市,用于前列腺癌的治疗。主要介绍帕利泊芬的发现历程与合成路线、药理作用以及临床研究进展,旨在为肿瘤光动力疗法的进一步探索提供参考。

Photodynamic therapy has been widely used in the treatment of tumors and has broad application prospect.Recent studies have shown that padeliporfin,a water-soluble vascular-targeting photosensitizer can selectively accumulate in tumor cells after intravenous administration and release a large amount of reactive oxygen species upon photoactivation,thereby exerting anti-tumor effect.This drug has been approved in Europe as a treatment for prostate cancer.This review mainly introduced the discovery process,synthetic route,pharmacological action and clinical research progress of padeliporfin,so as to provide reference for further exploration of tumor photodynamic therapy.