安定保留灌肠与静脉给药治疗小儿惊厥的比较分析

Comparison Analysis of Diazepam Retention Enema and Intravenous Administr Ation for Treating Children Convulsion

目的:比较安定保留灌肠与静脉给药治疗小儿惊厥的效果及安定对呼吸抑制副作用的比较。方法:2005年9月-2013年7月对我院门诊急救的70例小儿惊厥患儿随机分为两组:用剂量相同的安定保留灌肠组(观察组)及安定静脉注射给药组(对照组),每组35例,比较两组患儿用安定后的起效、维持时间及药物的呼吸抑制副作用。结果:两组患儿起效及维持时间比较差异无统计学意义(P>0.05);药物的呼吸抑制的副作用比较差异有统计学意义(P<0.01)。结论:用剂量相同的安定保留灌肠与静脉给药的起效及维持时间无明显差异,但安定保留灌肠未出现静脉给药的呼吸抑制副作用,且操作简单。安定保留灌肠法治疗小儿惊厥具有安全、起效快、易操作、实用性强,以便推广使用。

Objective:To compare the effect of diazepam retention enema method and intravenous administration method for the treatment of children convulsion and explore respiratory depression side effect of diazepam .Methods:From September 2005 to July 2013 ,70 patients with children convulsion were admitted to our hospital ,they were randomly divided into the observa‐tional group treated with diazepam retention enema and the control group treated with intravenous administration .Each group has 35 samples and every patient has the same infection dose .Then compare the onset time and sustained time and respiratory depression side effect of two groups .Results:The differences of the onset and sustained time between two groups were not sig‐nificant(P>0 .05);the differences of respiratory depression side effect between two groups were significant (P<0 .01) .Conclu‐sion:There were no visible differences in onset and sustained time between two groups ,but diazepam retention enema method did not cause respiratory depression and it’s more pratical and convenient .