造血干细胞移植治疗恶性血液病13例疗效观察

Observation on Curative Effect of Hematopoietic Stem Cell Transplantation (HSCT) Methods in the Treatment of Malignant Hematological Diseases for 13 Patients

目的:探讨造血干细胞移植(HSCT)治疗恶性血液病的疗效和并发症。方法:对13例恶性血液病患者施行造血干细胞移植(HSCT),其中自体HSCT(auto-HSCT)9例,异基因HSCT(allo-HSCT)4例。结果:所有患者均成功造血重建。auto-HSCT和allo-HSCT后中性粒细胞恢复≥0.5×109/L,中位时间为16(9~29)d,PLT恢复≥20×109/L,中位时间为62(12~298)d;发生急性、慢性移植物抗宿主病分别为4、3例;auto-HSCT复发2例,死亡1例,alloHSCT死亡1例。结论:HSCT可以延长生存期,提高生活质量,是治疗恶性血液病的有效方法。

Objective :To investigate the clinical efficacy and complication of hematopoietic stem cell transplantation (HSCT) in 13 patients with malignant hematological disease .Methods :Thirteen patients with malignant hematological disease received HSCT ,including 9 cases of auto-HSCT ,4 cases of allo-HSCT .Results:All the patients had rapid he-mopoietic reconstitution .After auto-HSCT and allo-HSCT ,the time when the absolute neutrophil counts (ANC) were more than 0 .5 × 109/L were 9 and 29 days separately ,times of platelet count more than 20 × 109/L were 12 and 298 days separately ;acute and chronic graft-versus-host disease (GVHD) was observed in 4 and 3 cases separately ;2 cases relapsed and 1 case died in auto-HSCT group;1 case died in allo-HSCT group .Conclusion:HSCT has a good efficacy in the treatment of malignant hematological disease .It is suggested that the patients can get a obvious survival benefit from HSCT .