大剂量坦索罗辛治疗良性前列腺增生伴膀胱过度活动症的临床疗效观察

Clinical Effect Observation of High dose Tamsulosin in Treatment for Benign Prostatic Hyperplasia and Overactive Bladder

目的:探讨大剂量坦索罗辛治疗良性前列腺增生伴膀胱过度活动症的临床疗效。方法:选取本院2011年10月-2013年10月诊治的良性前列腺增生伴膀胱过度活动症患者92例,根据治疗方案分为两组,对照组46例患者采用索利那新治疗,观察组46例患者采用坦索罗辛治疗,疗程12周,给予患者国际前列腺症状评分和膀胱过度活动症评分,比较两组患者的膀胱痉挛、排尿及不良反应情况。结果:观察组患者国际前列腺症状评分、膀胱过度活动症评分均明显低于对照组,观察组患者膀胱痉挛时间、膀胱痉挛次数、尿急次数、尿频次数、夜尿次数均明显小于对照组,差异均有统计学意义(P<0.05)。观察组患者不良反应发生率低于对照组,差异均无统计意义(P>0.05)。结论:大剂量坦索罗辛可显著改善良性前列腺增生伴膀胱过度活动症患者临床病症,不良反应少且安全性高,值得推广使用。

Objective :To investigate clinical effect of high dose tamsulosin in treatment for benign prostatic hyperplasia and overactive bladder .Methods:92 patients with benign prostatic hyperplasia and overactive bladder were selected in hospital from June 2011 to June 2013 .According to treatment ,patients were divided into two groups .46 patients trea-ted solifenacin as control group .46 patients treated tamsulosin as observation group .Course of treatment was 12 weeks .Patients received international prostate symptom score and overactive bladder score .Bladder spasm ;urination;adverse reaction were compared between two groups .Results:International prostate symptom score and overactive blad-der score in observation group were significantly lower than control group .Bladder spasm time ;bladder spasm num-ber;urgency number ;frequent urination number ;nocturia number in observation group were significantly less than control group .Difference was statistically significant (P<0 .05) .Incidence of adverse reaction in observation group was lower than control group .Difference was not statistically significant (P>0 .05) .Conclusion:High dose tamsulosin can significantly improve clinical symptoms of patients with benign prostatic hyperplasia and overactive bladder ,which has less adverse reaction and high safety .That is worthy of clinical use .