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辛伐他汀治疗不稳定型心绞痛的疗效观察

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摘要 目的探讨辛伐他汀治疗不稳定型心绞痛的临床疗效。方法将116例不稳定型心绞痛(UAP)患者随机分为治疗组和对照组。每组58例,对照组给予阿司匹林、血管紧张素转换酶抑制剂、β受体阻滞剂、低分子肝素及硝酸酯类治疗。治疗组在对照组治疗的基础上加服辛伐他汀40 mg,qd。2组疗程均为1个月。结果治疗组心绞痛的改善程度与对照组比较有统计学差异(P<0.05)。结论辛伐他汀治疗UAP,能稳定动脉粥样硬化斑块,显著改善心绞痛的症状。
作者 陈海生
出处 《基层医学论坛》 2007年第S1期41-42,共2页 The Medical Forum
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  • 1[1]TREASURE C B,KLEIN J L,WEINTRAUB W S,et al.Beneficial effects of cholesterol-lowering therapy on the coronary on the endothelium in patients with coronary artery disease[J].N Engl J Med,1995,332(8):481-487.
  • 2[2]ANDERSON T,MEREDITH I,YEUNG A,et al.The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary[J].N Engl J Med,1995,332(8):488-493.
  • 3[3]DUPUIS J,TARDIF J,CERNACEK P,et al.Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes:the RECIFE(Reduction of cholesterol in Ischemia and Function of the Endothelium)trial[J].Circulation,1999,99(25):3227-3233.
  • 4[4]ULRICH L,FATA V L,PLUTZKY J,et al.Upregulation of endotheliual nitric oxide synthase by HMG CoA reductase inhibitors[J].Circulation,1998,97(12):1129-1135.
  • 5[5]LACOSTE L,LAM J Y,HUNG J,et al.Hyperlipidemia and coronary disease: correction of the increased thrombogenic potential with cholesterol reduction[J].Circulation,1995,92(1):3127-3177.
  • 6[6]RIDKER P M,CUSHSHMAN M,STAMPFER M J,et al.Inflammation,aspirin and risk of cardiovascular disease in apparently healthy men[J].N Engl J Med,1997,336(14):973-979.
  • 7[7]BICKEL C,RUPPRECHTT H J,BLANKENBERG S,et al.Non-lipid lowering effects of statin medication in patients with coronary heart disease[J].J Am Coll Cardiol,2000,35(1):256A.
  • 8[8]INOUE I,GOTO S,MIZOTANI K,et al.Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect reduction of MRNA levels for interleukin-1β,interleukin-6,cyclooxygenase-2,and p22phox by regulation of peroxisome proliferator-activated receptorα(PPARα)in primary endothelial cells[J].Life sciences,2000,67(8):863-876.
  • 9[9]SINDERMANN J,WEIGEL K,MULLER J G,et al.Induction of p53 and interleukin by HMG CoA reductase inhibitors in human coronary smooth muscle cells[J].EurHeartJ,1997,18(3):371.
  • 10Laufs U,Fata VL,Pluteky J,et al.Upregulation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors.Circulation,1998,97:1129

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