摘要
改进抗肿瘤药泊马度胺的合成工艺,以3-硝基邻苯二甲酸为原料,合成3-硝基邻苯二甲酸酐;再与谷氨酰胺反应,经氨解、缩合、还原得到目标产物泊马度胺,反应总收率60.8%。
This study is to optimize production of antitumor agent pomalidomide. The 3-nitrophthalic anhydride was synthesized from 3-nitrophthalic acid and then reacted with glutamine, and the final product pomaliddomide was synthesized by ammonolysis, condensation and reduction. The total yield is 60.8%.
出处
《药学与临床研究》
2016年第3期242-243,共2页
Pharmaceutical and Clinical Research
基金
国家自然科学基金项目(81473692)
关键词
泊马度胺
工艺改进
合成
Pomaliddomide
Process optimization
Synthesis
