代谢流分析在肿瘤代谢研究中的应用进展

Recent applications of metabolic flux analysis in tumor metabolism

代谢是生物体进行生命活动的基础,代谢紊乱与糖尿病、肿瘤、炎症等诸多疾病密切相关。代谢重编程是肿瘤细胞的重要特征之一,在正常细胞的癌变、肿瘤的进展和转移中均发挥重要作用。代谢流分析是研究肿瘤代谢的重要手段,其利用稳定同位素标记重要代谢物,并追踪其在生物体中的代谢方向和速率,从而揭示特定代谢途径的活跃程度和动态变化。近年来,代谢流分析被广泛用于肿瘤代谢的研究中,是发现肿瘤代谢新途径和代谢重编程新机制的重要工具。本文从肿瘤营养摄取、肿瘤特异性代谢途径等多方面对代谢流分析在肿瘤代谢研究中的应用进展进行综述。

Metabolism is fundamental for biological process. Metabolic disorders are closely related to many diseases such as diabetes, tumors and in?ammation. Metabolic reprogramming plays critical role in the transformation, progression and metastasis of cancer. Metabolic ?ux analysis is an important tool to study tumor metabolism by using stable isotopes to label important metabolites and traces its metabolism in organisms to learn the activity and dynamic changes of speci?c metabolic pathways. Recently, metabolic?ux analysis has been widely used in the study of tumor metabolism as an important tool for understanding new mechanisms of tumor metabolic reprogramming. This review briefs the recent applications of metabolic ?ux analysis in tumor metabolism studies such as nutrient sources for tumor growth, tumor-speci?c metabolic pathways, etc.