某医院乙型肝炎患者血清甲状腺激素水平测定结果分析

Analysis on Testing Results of Serum Thyroid Hormone Levels Among Patients with Hepatits B in a Hospital

[目的]探讨乙型肝炎(乙肝)患者血清甲状腺激素水平及其临床意义。[方法]采用放射免疫分析法,对解放军第91中心医院感染科2009年3月至2012年6月收治住院的86例乙肝患者(急性乙肝40例、慢性乙肝27例、肝硬化19例)进行血清总三碘甲腺原氨酸(TT3)、游离三碘甲腺原氨酸(FT3)、总甲状腺激素(TT4)、游离甲状腺激素(FT4)、促甲状腺激素(TSH)检测,并以30名健康体检者为对照。[结果]检测急性乙肝40例,慢性乙肝27例,肝硬变19例,健康对照30人。4组人群血清TT3、TT4、FT3、FT4值的差异均有统计学意义(P<0.01),TSH值的差异无统计学意义(P>0.05)。其中,TT3值,肝硬变组、慢性乙肝组均低于急性乙肝组、对照组;TT4值,肝硬变组、慢性乙肝组均低于急性乙肝组、对照组,急性乙肝组高于对照组;FT3值,肝硬变组、慢性乙肝组均低于急性乙肝组、对照组;FT4值,肝硬变组、慢性乙肝组均低于急性乙肝组;TSH值,肝硬变组低于急性乙肝组。以上各组之间的差异均有统计学意义(P<0.01或<0.05)。[结论]肝硬变和慢性乙肝患者血清TT3、TT4、FT4、FT4水平均有所降低,急性乙肝患者TT4水平有所升高,乙肝患者的TSH水平变化不明显。

[Objective]To explore the clinical significance and the levels of serum thyroid hormone in patients with hepatitis B(H.B).[Methods]A total of 86 patients with hepatitis B(acute hepatitis B 40 patients,chronic hepatitis B 27 patients,liver cirrhosis 19 patients) from March 2009 to June 2012 treated in the infectious department of NO.91central hospital of liberation army were chosen.They were detected in serum total triiodothy ronine(TT3),serum free triiodothy ronine(FT3),serum total thyroxine(TT4),serum free thyroxine(FT4),thyroid-stimulating hormone(TSH)by radioimmunoassay.30 cases with normal physical examination were chosen as the control group.[Results]The serum thyroid hormone levels in 40 acute hepatitis B,27 chronic hepatitis B,19 liver cirrhosis and 30 control group were tested,The levels of TT3,TT4,FT3,FT4 with four groups had significant difference(P<0.01).The levels of TSH had no significant difference compared with four group(P>0.05).Of those,the TT3 value of the liver cirrhosis group and the chronic hepatitis B group was lower than those acute hepatitis B and the healthy control group.The TT4 value of the liver cirrhosis group and the chronic hepatitis B group was lower than those acute hepatitis B and the healthy control group,the TT4 value of the acute hepatitis B group higher than those the healthy control group.The FT3 value of the liver cirrhosis group and the chronic hepatitis B group lower than those acute hepatitis B and the healthy control group.The FT4 value of the liver cirrhosis group and the chronic hepatitis B group lower than those acute hepatitis B.the TSH value of the liver cirrhosis group lower than those acute hepatitis B.there were significant difference between those groups(P<0.01 or P<0.05).[Conclusion]The levels of TT3,TT4,FT3,FT4 in liver cirrhosis and chronic hepatitis B patients have decreased,the levels of FT4 in acute hepatitis B patients are higher,and the levels of TSH have no significant change.