摘要
合成了一系列二甲氨基甲酸间-(烷氨基)烷氧基苯酯,并进行了实验动物的毒性和中麻催醒试验。初步临床观察表明,化合物Ⅱ_4(现命名为催醒安)比毒扁豆碱的催醒效果好,而毒性小。简要地讨论了结构和生物活性之间的关系。
A series of m-(alkylamino) alkoxylphenyl N,N-dimethyl carbamates were synthesized as potential analeptics in traditional medicine anesthesia. All compounds were tested for toxicity and analeptic activity in experimental animals. The results will be reported elsewhere.Preliminary clinical observations showed that compound Ⅱ_4, introduced under the name of "CUI XING AN", is less toxic and more effective than physostigmine as analeptic in traditional medicine anesthesia.Structure-activity relationships are briefly discussed.
出处
《药学学报》
CAS
1981年第2期105-110,共6页
Acta Pharmaceutica Sinica
