基于反向功效差异性特点的中药质量标志物研究思路——以三七为例

A hypothesis on the Q-markers based on characteristics of opposite-effect of herbs: an example of Sanqi

中药质量问题是现代中药研究中的一个热点问题。中药的"一物多效"的特点已被广泛接受和研究。本文提出中药反向功效是中药"一物多效"的特殊表现,并针对反向功效中药这一特殊类型,对常用中药中典型反向功效中药进行归纳,进而基于"质量标志物(Q-marker)"的研究理论,以典型的反向功效中药—三七为例,提出反向功效中药质量标志物研究的策略与方法。从中药的反向功效的差异性特点出发,通过现代药理研究手段对其相反的传统功效进行验证,开展化学物质组及其反向功效的相关性研究,确定反向功效的物质基础,进一步进行有效化学成分的作用靶点、通路等作用机制研究和化学成分的特有性分析,确定质量标志物,为对具有相反功效的一类中药进行精准质量控制提供有益的参考。

The quality definition of traditional Chinese medicine(TCM) is a hot area in modern research of TCM. In recent years, the characteristics of one herb with multiple effects have been widely accepted and studied.The typical opposite-effect of herbs is considered as a special part of one herb with multiple effects, and was summarized in this paper. Sanqi was used as an example of opposite-effect herbs for developing the strategies and approaches on the Q-markers. The traditional opposite-effect should be studied by modern pharmacological research methods. The correlation of the chemical components with the opposite effects should be established in order to verify the material basis and evaluate the mechanism including targets and pathways. The unique charac‐teristics of chemical components should be analyzed and defined. Finally, the Q-markers of the opposite effect herb will be confirmed. This paper provides a useful reference for the precise quality control of herbal opposite-effects.