摘要
离子液体因其高度可调性而具备优良的物理化学性质和独特的生物活性,已不再局限于作为溶剂的传统应用。随着对其毒性与生物相容性的深入了解,由于阴阳离子组合的多样性与可设计性,离子液体已经能够弥补市售药物在溶解度、生物利用度和药物输送等方面的不足,在药物开发中潜力巨大。本文通过对离子液体在药物合成、输送作用,以及作为药物活性成分和剂型改良方面的研究与应用进行阐述,并对离子液体药物的未来发展作出展望。
Ionic liquids are not limited to the traditional use of solvents because of their high permeability and excellent physicochemical and unique biological properties. Nowadays, with the deep understanding of their toxicity and biocompatibility, ionic liquids have been tailored as novel solutions to address potential problems of marketed drugs. Based on the research and development of modified new drugs, ionic liquids have been incorporated into drug synthesis and emerged as attractive environmental-friendly reaction media with milder reaction conditions, higher yields and easier reaction workups and drug delivery systems. In addition, they have been designed for effective drug carriers removing undesirable properties of solid drugs. Further, ionic liquids forming active pharmaceutical ingredients dedicated to the liquefaction of drugs for promising clinical applications.
作者
曹建平
牟永晓
陈媛媛
卫涛
王朝杰
CAO Jian-ping;MOU Yong-xiao;CHEN Yuan-yuan;WEI Tao;WANG Chao-jie(School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou 325035,China)
出处
《药学学报》
CAS
CSCD
北大核心
2019年第2期245-257,共13页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(21177098)
浙江省自然科学基金资助项目(LY16B070006)
关键词
离子液体
药物合成
药物输送
药物活性组分
临床应用
ionic liquid
drug synthesis
drug delivery
active pharmaceutical ingredient
clinical application
