摘要
蛋白翻译后修饰是一种蛋白功能调节的重要方式,对生理和病理条件下蛋白质的结构和功能都至关重要,且修饰种类繁多。肿瘤的免疫治疗是指通过激活体内的免疫细胞或使失能的免疫细胞正常化从而治疗肿瘤的有效方法。近年来研究发现,许多类型的蛋白翻译后修饰都参与了肿瘤微环境中免疫细胞的增殖、活化以及代谢重编程等过程,并可能影响肿瘤免疫治疗的疗效。因此,本文就几类不同蛋白翻译后修饰对肿瘤微环境中免疫细胞的作用进行综述,旨在为肿瘤免疫治疗提供新的思路。
Post-translational modifications(PTMs)of proteins is an important mode of protein function regulation,which is essential for the structure and function of proteins under physiological and pathological conditions,and the types of modifications is wide.Cancer immunotherapy refers to an effective method for cancer treatment by activating or normalizing disabled immune cells.In recent years,researchers have found that many types of PTM are involved in the process of proliferation,activation and metabolic reprogramming of immune cells in cancer microenvironment,and may affect the efficacy of cancer immunotherapy.Therefore,this article reviews the effects of several different PTMs on immune cells in cancer microenvironment,and aims to provide new ideas for cancer immunotherapy.
作者
金晶
季鸣
陈晓光
JIN Jing;JI Ming;CHEN Xiao-guang(State Key Laboratory of Bioactive Substances and Functions of Natural Medicines/Beijing Key Laboratory of Non-clinical Drug Metabolism and PK/PD Study,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)
出处
《药学学报》
CAS
CSCD
北大核心
2019年第10期1711-1717,共7页
Acta Pharmaceutica Sinica
基金
“十三五”国家“重大新药创制”科技重大专项(2018ZX09711001-003)
关键词
蛋白翻译后修饰
肿瘤
肿瘤微环境
肿瘤免疫治疗
post-translational modifications of proteins
cancer
cancer microenvironment
cancer immunotherapy
