抗CCP抗体与RF联合检测在类风湿关节炎早期诊断中的意义

Significance of Combined Detection of Anti-CCP Antibody and RF in Early Diagnosis of Rheumatoid Arthritis

目的探究抗CCP抗体与RF联合检测在类风湿关节炎早期诊断中的意义。方法选取2017年11月～2018年11月我院收治的30例类风湿关节炎患者设为研究组,另选取同期进行健康体检者30例设为对照组,对两组进行抗CCP抗体与RF联合检测,并且分析抗CCP抗体、RF单独及两者联合检测的敏感性、特异性、阳性预测值和阴性预测值。结果研究组抗CCP抗体阳性率96.67%、RF阳性率93.33%和两者联合检测阳性率86.67%均高于对照组的6.67%、3.33%及3.33%;研究组抗CCP抗体水平(78.65±14.33)U/ml和RF水平(314.22±20.56)IU/ml均高于对照组的(2.69±2.14)U/ml和(10.01±3.54)IU/ml(P<0.05)。结论对类风湿关节炎患者抗CCP抗体与RF的诊断敏感度拥有着一定的相似性,但抗CCP抗体特异度高于RF的特异度,若两者联合检测可极大提高敏感度,对于类风湿关节炎患者早期诊断工作的开展拥有着积极的推动作用。

Objective To explore the significance of combined detection of anti-CCP antibody and RF in the early diagnosis of rheumatoid arthritis.Methods 30 patients with rheumatoid arthritis admitted to our hospital from November 2017 to November 2018 were enrolled as the study group, and30 healthy controls were selected as the control group. Anti-CCP antibody and RF were administered to the two groups. Combined detection, and analysis of sensitivity, specificity, positive predictive value, and negative predictive value of anti-CCP antibody, RF alone, and a combination of both.Results The positive rate of anti-CCP antibody in the study group was 96.67%, the positive rate of RF was 93.33%, and the positive rate of combined detection was 86.67%, which was higher than 6.67%, 3.33% and 3.33% of the control group. The anti-CCP antibody level of the study group(78.65±14.33) U/ml and RF levels(314.22±20.56) IU/ml were higher than the control group(2.69±2.14) U/ml and(10.01±3.54) IU/ml(P<0.05).Conclusion There is a certain similarity between the anti-CCP antibody and RF diagnostic sensitivity in patients with rheumatoid arthritis, but the specificity of anti-CCP antibody is higher than the specificity of RF. If the combination of the two can greatly improve the sensitivity, for the class The early diagnosis of rheumatoid arthritis patients has a positive role to play.