肠道病毒71型感染相关遗传易感基因研究现状

Research status of genetic susceptibility genes of Enterovirus 71 infection

肠道病毒71型(EV71)是引起婴幼儿手足口病(HFMD)的最常见肠道病毒之一。EV71侵染取决于病毒、宿主及环境的多重作用,特别是介导EV71病毒与宿主固有免疫及适应性免疫反应功能异常相关基因的多态性与EV71易感关系密切。在此过程中,越来越多白细胞介素类(IL-4,IL-8,IL-17F和IL-18)、趋化因子类(MCP-1,IP-10)及抗病毒蛋白类(OAS,HLA)相关基因被筛选发现与EV71易感及病程恶化密切相关。本文就近年来EV71感染相关遗传易感基因筛选研究状况作一综述。

Enterovirus 71(EV71) is one of the most common intestinal virus that causes hand, foot and mouth disease in infants. EV71 infection depends on multiple factors including virus, host and environment,especially the genes polymorphism mediated host innate immunity and adaptive immunity dysfunction to EV71 virus are closely associated with susceptibility to EV71. In this process, more and more interleukins genes(IL-4,IL-8, IL-17 F and IL-18), chemokines(MCP-1, IP-10) and antiviral protein(OAS, HLA) related gene to be screened closely related to the susceptibility and deterioration of EV71 infection. Here, genetic susceptibility genes of Enterovirus 71 infection were reviewed.