耐碳青霉烯铜绿假单胞菌耐药性的基因学研究进展

Genetic research progress of carbapenems-resistant Pseudomonas aeruginosa

碳青霉烯类抗生素是治疗铜绿假单胞菌感染的有效药物,但随着此类抗生素的广泛应用,铜绿假单胞菌对碳青霉烯类抗生素的耐药率呈上升趋势。本文从药物的主动转运系统、抗菌药物渗透障碍、产生药物灭活酶及形成生物被膜这4个方面对耐碳青霉烯铜绿假单胞菌耐药性的基因学研究进行综述,为临床合理应用抗生素和进行感染防控提供理论依据。

Carbapenems are useful drugs for the treatment of Pseudomonas aeruginosa infection,but, with the wide use of these antibiotics, carbapenem-resistance is increasing in Pseudomonas aeruginosa. This review summarizes the advances in genetic research into the carbapenem-resistance of Pseudomonas aeruginosa with respect to the active transport system, antibacterial drug permeation barrier, producing drugs to inactivate enzymes and biofilm formation. The presented study provides a theoretical basis for the clinical rational use of antibiotics and prevention and control of infection.