血清NSE、CEA、CYFRA21-1、CA199、CA125、CA724联合检测对肺癌早期诊断的临床价值

Value of the NSE、CEA、CYFRA21-1、CA199、CA125、CA724 combined detection in the early diagnosis of lung cancer

目的:探讨联合检测血清神经特异性烯醇化酶(NSE)、癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)、糖类抗原125(CAl25)、72-4(CA72-4)和199(CAl99)对肺癌早期的诊断价值。方法:应用全自动电化学发光分析仪Cobas e601检测230例肺癌患者(肺癌组)、150例肺部良性疾病患者(肺部良性病变组)和50例健康体检者(对照组)血清中这六种肿瘤标志物血清水平,并进行统计学分析。结果:肺癌组六种肿瘤标志物血清水平明显高于肺部良性病变组和对照组(P<0.001),在六种肿瘤标志物不同组合中,以六项联合检测对肺癌诊断灵敏度(95.2%)和准确度(85.0%)最高。结论:肿瘤标志物联合检测可有效提高肺癌早期诊断的敏感度和准确度,能为临床及时治疗提供依据,值得临床应用。

Objective To explore the value of NSE、CEA、CYFRA21-1、CA199、CA125、CA724 combined detection in the early diagnosis of lung cancer. Methods Serum levels of the Six kinds of tumor markers in 230 patients with lung cancer(LC), 150 patients with benign lung diseases(BL) and 50 normal controls(NC) were measured by automatic electrochemical luminescence analyzer Cobas e601, and statistical analysis. Results The lung cancer group showed obviously higher serum Six kinds of tumor markers levels than those in the benign lung group and the healthy control group(P <0.001).There is highest of lung cancer diagnosis sensitivity(95.2%) and the highest accuracy(85.0%) by combined detection six tumor markers.Conclusion The combined detection Tumor markers can effectively improve the sensitivity and accuracy in early diagnosis of lung cancer, and provide basis for clinical treatment, It is worthy of clinical application.