DCE-MR在偏头痛微循环与肝阳上亢证候分型中的研究价值

Value of DCE-MR in Migraine Microcirculation and Syndrome Classification of Liver Yang Hyperactivity

目的:探讨磁共振动态增强扫描(DCE-MR)评价高血压偏头痛微循环改变及对中医证候分型的价值。方法:选取20例高血压偏头痛患者(肝阳上亢证型10例、非肝阳上亢型10例)与10名健康对照者,行DCE-MR检查,使用Omni-Kinetic软件分析每组颅底肌肉容积转移常数Ktrans,血管外细胞外容积比Ve,速率常数Kep,比较三组间差异。结果:肝阳上亢证偏头痛组、非肝阳上亢证偏头痛组与健康组Ktrans、Kep及Ve均存在差异(P <0.05);但肝阳上亢证组与非肝阳上亢证组Ktrans、Kep及Ve比较均无统计学意义,即增强效果无差别(P> 0.05)。结论:DCE-MR能客观评价高血压偏头痛患者微循环异常,但并不能完全区分肝阳上亢中医证候分型。

Objetive To explore the value of DCE-MR in evaluating the microcirculation changes of hypertensive migraine and the classification of TCM syndromes.Methods 20 patients with hypertension migraine(10 of hyperactivity of liver yang hyperactivity,10 of non liver hyperactivity type)and 10 healthy controls were examined by DCE-MR.Analysis of Ktrans,Kep and Ve of each group of skull base muscles,between the three groups the difference was compared.Results There were differences in Ktrans,Kep and Ve in migraine group,non liver yang hyperactivity syndrome migraine group and healthy group(P<0.05),but there was no statistical significance in the liver yang hyperactivity syndrome group and the non liver yang hyperactivity syndrome group,that means the enhancement effect was no difference(P>0.05).Conclusion DCE-MR can objectively evaluate the microcirculation abnormality of hypertensive migraine patients,but it can not completely distinguish the TCM syndrome types of hyperactivity of liver-yang.