CT值增加值均值的临界判断值在骨巨细胞瘤临床诊断中的敏感度分析

Research on the added value of CT values mean the critical value of sensitivity analysis in the clinical diagnosis of giant cell tumor of bone

目的:探讨CT值增加值均值的临界判断值在骨巨细胞瘤临床诊断中的敏感度。方法:采用回顾性分析法,选取120例骨肿瘤患者的临床资料,按照肿瘤诊断结果将其分为对照组和观察组,每组60例。观察组为骨巨细胞瘤患者,对照组为非骨巨细胞瘤患者。每例患者选择3个感兴趣区(ROI),将增强后CT值均值和CT值增加值均值作为观测值,在医师的观测下分析患者骨巨细胞瘤的CT值增加值均值的临界判断值及其在骨巨细胞瘤临床诊断中的灵敏度。结果:观察组患者CT增强扫描后显示区域平均CT值为(108±39)HU,明显高于对照组(82±78)HU的CT值,其差异有统计学意义(t=3.348,P<0.05);通过受试者操作特征(ROC)曲线分析,发现当CT值增加值均值≥96.5为临界点时,诊断骨巨细胞瘤的敏感度和特异性分别为90.9%和62.0%;当CT值增加值均值≥41.5 HU为临界点时,诊断巨骨细胞瘤的敏感度和特异性分别为98.9%和48.1%。结论:骨巨细胞CT值增加值均值诊断临界值为96.5 HU和41.5 HU时的灵敏度高,但是特异度较低,CT值增加值有助于判断骨巨细胞瘤的存在。

Objective: To investigate the CT value added value of the mean of critical value in the diagnosis of giant cell tumor clinical sensitivity. Methods: Aretrospective analysis, selected from March 2013 to November 2014, the clinical data of 120 patients with bone tumors treated, they can be divided into two groups at random, control group and the observer, 60 cases in each group, observer for patients with giant cell tumor of bone, the control for the patients with giant cell tumor of bone. Each patient chose three ROI, the added value of the mean values of enhanced CT and CT values mean as observed values, under the experience of observation analysis of patients with giant cell tumor of the added value of CT values mean critical value and its sensitivity in the clinical diagnosis of giant cell tumor of bone. Results: The observation group of patients after CT enhanced scan display area average CT value of HU(108±39)HU was significantly higher than the control group(82±78)HU CT value(t=3.348, P<0.05), statistically significant difference; Through the ROC curve analysis, found that when the added value of CT values mean acuity 96.5 as critical, sensitivity and specificity of diagnosis of giant cell tumors of bone are 90.9% and 90.9% respectively; When the CT value added value of the mean acuity 41.5 HU as the critical point, the sensitivity and specificity of diagnosis of giant cell tumor bone were 98.9%, 48.1% respectively. Conclusion: The bone giant cell average CT value added value of diagnosis of critical value of 96.5 HU 41.5 HU, and high sensitivity, but the specificity is low, the added value of CT values help determine the existence of the giant cell tumors of bone.