滤泡性辅助性T细胞的研究进展

Research Progress in Follicular Helper T Cells

滤泡辅助T细胞(Tfh)在免疫反应中具有重要作用。Tfh细胞的分化是一个多阶段多因子的过程,其中涉及多种转录因子的参与;Tfh细胞同时也是保护性免疫性反应中的关键环节,因此利用Tfh细胞提高免疫接种策略方面有广阔的研究前景。Tfh同样在一些疾病的发生过程中扮演重要角色,但这是个新兴的领域,仍需要大量的研究将Tfh细胞生物学的知识应用到医学相关治疗方面。

Follicular helper T( Tfh) cells are essential for immune response of human bodies. Tfh cell differentiation is a multistage,multifactorial process involving many transcription factors. Tfh cells are critical components of many protective immune responses against pathogens. As such,there is strong interest in harnessing Tfh cells to improve vaccination strategies. Tfh cells also have roles in a range of other diseases.Overall,there have been dramatic advances in this young field,but there is still much to be learned about Tfh cell biology in the interest of to the application in the medical needs.