摘要
糖尿病肾病(DN)是糖尿病常见的微血管并发症,也是糖尿病患者主要致死、致残的原因。该文简要阐述了DN病理学机制不同方面的三个标志物——血清同型半胱氨酸(Hcy)、胱抑素C(CysC)和可溶性细胞间黏附分子1(sICAM-1),综述了与DN病理学机制不同角度相关的血清生物标志物及尿微量白蛋白对DN早期检测的意义,并进一步阐述联合检测对于DN早期诊断及防治的潜在价值,为今后提高DN早期检测阳性率及进一步探讨DN诊断指标提供了一定的理论依据。
Diabetic nephropathy( DN) is one of the common microvascular complications of diabetes,which is also the main reason of death and disability. Here is to briefly introduce the research status of DN pathogenesis,and discuss the relationship among serum homocysteine,cystatin C,soluble intercellular adhesion molecule-1,summarizing the significance and potential value of those biomarkers and microalbumin in detection of incipient DN,which will provide,to some extent,a basis for how to improve positive rate and diagnosis index in the early detection of DN.
出处
《医学综述》
2016年第10期1945-1948,共4页
Medical Recapitulate
基金
云南省教育厅科学研究基金(2013Y286)
