摘要
吉兰-巴雷综合征(GBS)是引起急性迟缓性瘫痪的常见病因之一,以迅速进展的对称性肢体无力或感觉异常为特征,严重影响患者的日常生活。GBS与自身免疫反应密切相关,由前驱感染引起免疫系统错误识别周围神经髓鞘与病原体,造成神经髓鞘脱失甚至轴索损害。静脉注射人免疫球蛋白、血浆置换是治疗GBS的有效措施,但仍然有部分患者遗留运动或感觉异常。目前有关GBS发病机制及诊疗的相关研究也有了更深入的进展。
Guillain-Barré syndrome( GBS),also known as acute inflammatory demyelinating polyradiculoneuropathy,is an acute-onset,immune-mediated disorder of the peripheral nervous system characterized by rapidly progressive,symmetrical weakness of the extremities. GBS is closely related to autoimmune reaction:the antecedent infection caused immune system mistaken identification of peripheral nerve myelin sheath and pathogens,causing nerve demyelination and axonal damage. Intravenous immunoglobulin and plasma exchange are proven effective treatments but many patients have considerable residual motor or sensory deficits. Notable advances have been made in the pathogenesis,diagnosis and therapies of GBS.
出处
《医学综述》
2016年第10期1963-1966,共4页
Medical Recapitulate
