炎性因子与免疫性血栓的相关性研究进展

Research Progress of Correlation between Inflammatory Cytokine and Immunothrombosis

免疫调节紊乱使得自身免疫性疾病频发免疫性血栓,进而损伤重要脏器功能,甚至导致死亡,从而增加了临床治疗的复杂性。且免疫性血栓与炎症反应呈高度相关性,免疫性炎症反应不仅可以直接损伤血管内皮细胞,促进凝血反应,还能诱导凝血系统表达炎性因子,从而扩大炎症反应和增强凝血过程,所以炎症反应越严重,凝血系统就越活跃。因炎性因子对免疫性血栓的形成影响明显,故以此为靶点进行干细胞治疗可能会成为新的临床治疗方法。

Immune disorders such as autoimmune diseases may frequently cause autoimmune thrombosis,and thus damage the vital organ function,and even lead to death,thereby increases the complexity of the clinical treatment. Thrombosis and inflammation and autoimmune were highly correlated,autoimmune inflammatory response not only can directly damage vascular endothelial cells,promote blood clotting response,but also induce the expression of inflammatory cytokines in coagulation system,thereby increase inflammation and enhance the clotting process,so the more severe the inflammation is,the more active the coagulation system is. Because autoimmune inflammatory factors significantly affect the formation of blood clots,the target stem cell therapy may become a new clinical treatment.