精神分裂症风险基因多态性的研究进展

Research Progress in Risk Gene Polymorphism of Schizophrenia

精神分裂症是一类变异性很大的精神病性障碍,其发病机制尚不清楚,目前认为是遗传与环境因素共同作用导致神经发育异常的结果。遗传因素中风险基因单个核苷酸多态性(SNPs)与精神分裂症发病机制的相关性引起了重视。目前,SNPs研究主要集中在与神经发育异常相关的领域,涵盖了与神经营养、神经递质、代谢酶类等基因的研究。除此之外,在免疫学等其他领域的相关基因也有类似的报道。

Schizophrenia is a psychotic disorder of great variability,the pathogenesis of which is still not clear,but it is generally agreed that the genetic and environmental factors together lead to abnormal neurodevelopmental outcome. Correlations between single-nucleotide polymorphisms( SNPs) and schizophrenia pathogenesis have attracted the attention. Currently,the genetic researches are focused on neurodevelopmental abnormalities,covering genes research on neurotrophic,neurotransmitters,metabolic enzyme and other field.In addition,similar reports of related genes are also seen in other areas such as immunology.