YAP蛋白在大肠新生物发生发展中的研究进展

Research Advances in Role of Yes-Associated Protein in the Development of Colorectal Neoplasia

大肠癌是最常见的恶性肿瘤之一,随着内镜早期筛查诊断的普及和手术药物等治疗方法的改进,患者预后已有较大改善,但病死率仍较高,故需进一步阐述其发生的分子机制,以寻求更好的诊断方法、预后指标和治疗方法。YAP蛋白作为共转录因子,参与调控细胞增殖和凋亡相关基因的表达,可与在大肠癌发生发展中起重要作用的Wnt/β联蛋白通路及APC蛋白交叉协同。当前,围绕YAP蛋白作为致癌因子及潜在药物靶点机制的研究吸引了许多学科的关注。

Colorectal cancer is one of the most common malignant tumors. With the popularization of endoscopic diagnosis for early stage colorectal cancer and the progress of surgical and medical treatments,the patient prognosis has improved greatly,but the mortality remains high,so the molecular mechanism still needs to be further elaborated to seek better diagnosis method,prognosis biomarker and treatment method. Yes-associated protein( YAP) as a transcription factor,participates in the regulation of cell proliferation and apoptosis and interacts with Wnt/β-catenin pathway and adenomatous polyposis coli( APC) protein in the development of colorectal cancer. Currently,the mechanistic research on YAP protein as an oncogene and potential drug target mechanism has attracted attention from many disciplines.