增乳方对左旋多巴诱导的哺乳大鼠低泌乳素血症的逆转作用

Reverse effects of composite lactogenic decoction on hypoprolactinemia induced by L-dopa in rats

目的 :研究增乳方 (CLD)对左旋多巴诱导的低泌乳素血症哺乳大鼠乳汁分泌的促进作用。方法 :采用左旋多巴 (L Dopa)诱导建立哺乳大鼠乳汁分泌低下模型 ;大鼠ig给予CLD ,观察不同剂量 (3、6、2 0g·kg-1·d-1)CLD对哺乳期大鼠的仔鼠体重以及母鼠血清泌乳素 (PRL)和乳腺组织学的影响。结果 :大鼠给予CLD 3、6、2 0g·kg-1·d-1,血清PRL值显著高于模型组 (P <0 .0 5 ,P <0 .0 1) ,呈量 效关系 ;CLD可明显增加母鼠泌乳量 ,促进仔鼠体重的增长 (P <0 .0 5 )并促进母鼠乳腺的发育。结论 :CLD对L Dopa诱导的哺乳大鼠低泌乳素血症具有逆转作用 。

AIM: To study the effects of the composite lactogenic decoction (CLD) on milk secretion of hypoprolactinemia induced by L dopa in rats. METHODS: The models of hypoprolactinemia were established with L dopa in rats. The weight of young rats was recorded during 15 days. Levels of serum prolactin were detected by ELISA and the mammary gland histology was observed by electron microscop. RESULTS: The administration of CLD (3, 6 and 20 g·kg -1 ) by the way of ig increased serum prolactin (PRL) level significantly (P< 0.05 or 0.01 ) induced by L dopa in rats at a dose dependent manner. CLD increased the weight of young rats (P< 0.05 ) and promoted the mammary grand growth of rats. CONCLUSION: CLD can reverse the symptom of hypoprolactinemia induced by L dopa and promote the secretion of milk in rats.