摘要
目的 :观察 4 甲基哌嗪 1 二硫代甲酸 (3 氰基 3,3 二苯基 )丙酯盐酸盐 (Hyd)对小鼠移植性肿瘤的抑制作用 ,以确定该化合物的应用前景。方法 :采用小鼠肉瘤 180和肝癌 2 2及人胃癌异种移植裸鼠肿瘤模型 ,观察Hyd对小鼠移植性肿瘤生长的影响。结果 :通过口服灌胃给药 ,不同浓度Hyd对小鼠移植性肉瘤S180 抑制率可达到 4 6 .4 %~ 5 9.6 % (P <0 .0 1~ 0 .0 0 1) ;对小鼠移植性肝癌H2 2 抑制率可达到39 .3%~ 5 1.6 % (P <0 .0 5~ 0 .0 0 1) ;对裸鼠人胃癌异种移植瘤的抑制率可达到 18.1%~ 5 9.0 %。结论 :Hyd对小鼠移植性肝癌H2 2 和小鼠移植性肉瘤S180 有明显抑制作用 。
AIM: To study the inhibition effects of the hydrochloride 4 methyl piperazine 1 carbodithioc acid 3 cyano 3,3 diphenyl propyl ester (Hyd) on the growth of transplant carcinoma in mice. METHODS: The growth of tumor was observed by models of transplant tumor in mice. RESULTS: The inhibition rates of Hyd against tumor growth of S 180 and H 22 implanted human gastric carcinoma were 46.4 %- 59.6 %, 39.3 %- 51.6 % and 18.1 %- 59.0 %, respectively in nude mice. CONCLUSION: Hyd can inhibit the growth of transplanted hepatocyte carcinoma 22, sarcoma 180 in mice, and implanted human gastric carcinoma in mice and nude mice.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2004年第1期59-62,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
国家自然基金资助项目 (№ 2 0 172 0 0 6)
国家重点科技项目 (№ 96 90 1 0 2 0 8)