山莨菪碱对脑外伤后急性肾损害大鼠血浆、肾组织匀浆孤啡肽含量变化的影响

Effects of Anisogamini Hydrochloridum on level of Orphanin FQ in the plasma and Kidney organizes of rat with brian trauma

目的探讨山莨菪碱对颅脑损伤后发生急性肾损害时血浆、肾组织中孤啡肽含量变化的影响及治疗作用。方法通过RIA方法测定大鼠脑损伤以及山莨菪碱治疗后血浆及肾组织匀浆孤啡肽含量的变化。结果脑损伤组血浆、肾组织匀浆中孤啡肽含量明显高于对照组(P<0.01),山莨菪碱治疗组血浆、肾组织匀浆中孤啡肽含量明显低于脑损伤组(P<0.01)。结论血浆及肾组织匀浆中孤啡肽含量增高可能是参与脑损伤后的急性肾损伤过程中的一个重要因素;山莨菪碱通过降低血浆及肾组织孤啡肽含量,而发挥对脑损伤后急性肾损伤一定的保护作用。

Objective To observe the effects of Anisogamini Hydrochloridum on levels of Orphanin FQ in the plasma and Kidney organizes with brian trauma. Methods The levels of Orphanin FQ in the plasma and Kidney organizes with brian trauma and administration of Anisogamini Hydrochloridum were determined by RIA . Results Levels of Orphanin FQ in the plasma and Kidney organizes of rat with brian trauma increased significantly, but decreased markedly after administration of Anisogamini Hydrochloridum. Conclusion Orphanin FQ may play some important roles in causing Kidney injury with brian trauma, and Anisogamini Hydrochloridum can improving Kidney injury by decreasing levels of Orphanin FQ.