甲氯芬酯治疗新生儿缺氧缺血性脑病的研究

Clinical Study on meclophenoxate in the treatment of neonatal hypoxic - ischemic encephalopathy

目的探讨甲氯芬酯治疗新生儿缺氧缺血性脑病的临床疗效。方法将92例HIE患儿随机分为治疗组与对照组,在常规治疗的基础上,治疗组加用甲氯芬酯静滴,每次60-100mg,每日1次,连用7天.观察两组患儿临床症状消失时间、治疗前后NBNA评分,检测脑血流动力学指标。结果治疗组有效率89.6%,治疗后NBNA评分结果及脑血流动力学参数与对照组比较有显著性差异。结论甲氯芬酯能改善患儿的脑血流动力学,促进临床症状、体征的恢复。

Objective To study the potential therapeutic effect of meclophenoxate on neonatal hypoxic - ischemic encephalopa-thy (HIE). Methods 48 caces were treated additinally with meclophenoxate in does of 60 - lOOmg peday for 7 days as the therapeutic group,and 44 cases with routine therape as the control group. The disappearance time of the clinical sysmptoms and singns,the neonatal behavioral neurological assessment (NBNA) score and cerebral hemodynamic were recorder. Results Total curative effect in the trent-ment group of 48 cases were 89. 6% respectixily, it was singnifiantly defferent from that of the control group . NBNA scores and cerebral hemodynamic parameters in the Treatment group was signitiantly different from that of control group. Conclusion Meclophenoxate can obviously improve HIE children's cerebral blood flow dynamics and shorten the disappearance time of chnical symptoms and signs.