某院慢性阻塞性肺疾病急性加重期全身应用糖皮质激素情况分析

Analysis on Systemic Use Situation of Glucocorticoids for Acute Exacerbation of Chronic Obstructive Pulmonary Diseases in a Hospital during 2012

目的了解医院慢性阻塞性肺疾病急性加重期(AECOPD)患者全身应用糖皮质激素类药物的情况,为临床安全、合理用药提供参考。方法查阅医院2012年1月至6月糖皮质激素类药物全身应用治疗AECOPD患者病历214份,对病历中糖皮质激素类药物的使用品种、给药途径、剂量、疗程、合并用药、不良反应等情况进行回顾性分析。结果在调查病历中单次给药剂量和用药疗程基本符合评价标准,但对无糖尿病、高血压使用了全身糖皮质激素患者在监测不良反应时应加强。结论延长静脉给药时间与吸入性给药相比并不能增加疗效,反而会增加全身不良反应的发生。

Objective To understand the systemic use situation of glucocorticoids in the patients suffering from acute exacerbation of chron-ic obstructive pulmonary diseases(AECOPD)in a hospital to provide reference for clinical safe and rational drug use. Methods 214 cas-es of medical records of AECOPD using systemic glucocorticoids from January to June 2012 were consulted. Then,the variety,administration route,dosage and course of treatment of glucocorticoiuds,drug combination and adverse drug reactions were retrospectively analyzed. Results Among the investigated medical records,the single dosage and treatment course basically accorded with the evaluation standard,but the ADR monitoring in those without diabetes or hypertension should be strengthened. Conclusion Compared with inhaled glucocorticoids,pro-longing the time of intravenous glucocorticoids does not increase the curative effect,but increases the occurrence of systemic ADR.