摘要
目的对比分析不同剂量的利伐沙班对急性冠脉综合征的治疗效果,并提出相应的护理策略。方法选取住院治疗的73例患者,随机分为对照组23例、低剂量组26例和高剂量组24例,对照组给予阿司匹林联合氯吡格雷治疗,低剂量组给予2.5 mg剂量的利伐沙班治疗,高剂量组给予5 mg剂量的利伐沙班治疗,且给予所有患者针对性护理干预,分别对3组的不良反应、血小板聚集率、肌酸激酶同工酶(CKMB)和肌钙蛋白(cTNI)进行监测。结果给予利伐沙班治疗的两组的不良反应发生率显著低于对照组(P<0.05),低剂量组显著低于高剂量组(P<0.05);给予利伐沙班治疗的两组对血小板聚集率及心肌梗死标记物的改善显著优于对照组(P<0.05),低剂量组与高剂量组不存在显著的统计学差异(P>0.05)。结论低剂量的利伐沙班对急性冠脉综合征具有很好的治疗效果,不良反应发生率低,且实施针对性护理干预有助于患者的康复,值得临床推广。
Objective To compare the effects of different doses of rivaroxaban for treating acute coronary syndrome and to propose the corresponding care strategy. Methods 73 cases of acute coronary syndrome treated in our hospital were selected as the research sub-jects and randomly divided into the control group(23 cases),low dose group(26 cases) and high dose group(24 cases). The control group was given aspirin combined with clopidogrel,the low dose group was given rivaroxaban 2. 5 mg and the high dose group was giv-en rivaroxaban 5 mg. All the cases were performed the pertinent nursing intervention. The adverse reactions,platelet aggregation rate,cre-atine kinase MB(CKMB)and troponin(cTNI)were monitored. Results The occurrence rate of adverse reactions in the low dose and the high dose groups was significantly lower than that in the control group( P < 0. 05),the low dose group was significantly lower than that in the high dose group( P < 0. 05);the platelet aggregation rate and the improvement of myocardial infarction markers in these two rivaroxaban groups were significantly superior to those in the control group( P < 0. 05),no statistical differences existed between the low dose group and the high dose group( P > 0. 05). Conclusion Low dose rivaroxaban has the better therapeutic effect and the low oc-currence rate of adverse reactions for treating acute coronary syndrome;implementing the pertinent nursing intervention on acute coronary syndrome conduces to the patient' s recovery and deserves to be clinically promoted.
出处
《中国药业》
CAS
2014年第12期34-36,共3页
China Pharmaceuticals
