3种常用抗病毒中药注射剂的配伍观察

Compatibility Observation of Three Kinds of Commonly Used Antiviral Chinese Medicine Injection

目的观察并分析双黄连、穿琥宁和清开灵3种常用抗病毒中药注射剂的临床配伍反应。方法将双黄连、穿琥宁和清开灵3种常用中药注射剂分别溶于5%和10%葡萄糖注射液、葡萄糖氯化钠注射液、0.9%氯化钠注射液几种常用注射液中,静置6 h,分别测定30 min和6 h时粒径不小于10μm或25μm的微粒数。再将上述3种常用抗病毒注射剂分别与几种常用青霉素类、头孢菌类、氨基苷类、喹诺酮类抗菌药物及几种常用维生素等进行配伍,观察其浑浊度(产生沉淀与否)。结果 30 min时,双黄连与5%和10%葡萄糖注射液、葡萄糖氯化钠注射液、0.9%氯化钠注射液配伍不小于10μm的微粒均在10粒以上,不小于25μm的微粒均在2粒以下;穿琥宁、清开灵与以上溶液的配伍不小于10μm的微粒均在10粒以下,不小于25μm的微粒均在2粒以下。6 h后,穿琥宁与以上溶液配伍不小于10μm的微粒均在10粒以下,不小于25μm的微粒均在2粒以下;双黄连、清开灵与以上溶液配伍不小于10μm的微粒均在10粒以上,不小于25μm的微粒均在2粒以上。3种抗病毒中药注射剂均与不同的西药抗菌药物存在配伍禁忌。结论穿琥宁与5%和10%葡萄糖注射液、葡萄糖氯化钠注射液、0.9%氯化钠注射液混合后较为稳定,双黄连、清开灵与以上溶液配伍后稳定性较穿琥宁差。双黄连、穿琥宁和清开灵3种常用中药注射剂与部分抗菌药物存在配伍禁忌,使用时需注意。

Objective To observe and analyze the clinical compatibility reaction of three kinds of common used antiviral Chinese medicine injection: Shuanghuanglian Injection, Chuanhuning Injection and Qingkailing Injection. Methods Shuanghuanglian Injection, Chuanhuning Injection and Qingkailing Injectio were dissolved in 5% and 10% glucose injection, glucose and sodium chloride injection, 0. 9% sodium chloride injection for 6 h standing. The particles in sizes of 10 μm and 25 μm were detected at 30 min and 6 h re-spectively. Then the above 3 kinds of common used antiviral injection were mixed with several kinds of common used western medicine antibacterial drug penicillins, cephalosporins, aminoglycosides and quinonones as well as some commonly used vitamins for observing the turbidity degree(whether producing sediment) . Results At 30 min, the number of particles 10 μm in the compatibility solution of Shuanghuanglian Injection with 5% and 10% glucose injection, glucose and sodium chloride injection and 0. 9% sodium chloride injec-tion was more than 10 particles, which of paricles 25μm was leass than 2 particles; number of particles 10 μm in the compatibility so-lutions of Chuanhuning and Qingkailing mixed with the above injections was less than 10 particlas and which of 25 μm was less than 2 particles. After 6 h, the number of particles 10 μm in the compatibility solution of Chuanhuning mixed with the above injections was less than 10 particles, which of paricles 25 μm was leass than 2 particle; the number of particles 10 μm in the compatibility solution of Shuanghuanglian Injection and Qingkailing Injection mixed with the aboce injections was more than 10 particles and which of paricles 25 μm was more than 2 particles. The incompatibility existed in these 3 kinds of antiviral Chinese medicne injections mixing with dif-ferent wetsern medicine antibacterial injections. Conclusion The mixed solutions of Chuanhuning Injection with 5% and 10% glucose injection, glucose and sodium chloride injection, 0. 9% sodium chloride injection are relatively stable, but the stability is poor after the compatibility of Shuanghuanglian Injection and Qingkaining Injection mixing with above injections. These three kinds of Chinese medicine injection are incompatible with some antibacterial drugs. When using, more attention should be paid to.