2012年我院346例药品不良反应报告分析

Analysis on 346 Cases of Adverse Drug Reaction Report in Our Hospital

目的分析医院药品不良反应(ADR)发生的原因与特点,为临床合理用药提供依据。方法对医院2012年1月1日至12月14日上报的364例ADR报告进行回顾性分析,按照药品不良反应涉及的患者性别、年龄、给药途径、药品类别、累及器官/系统及临床表现,各器官系统涉及的药品、因果关系评价、转归等进行统计和分析。结果静脉给药方式ADR发生率最高(51.73%);心血管系统药物引起的ADR居首(34.10%),其次为抗肿瘤药(16.76%),第3位为抗微生物药(13.00%);临床表现以消化系统损害最常见(28.71%);绝大多数发生ADR的患者能痊愈(33.24%)和好转(56.94%)。结论加强ADR监测和报告,可促进临床合理用药,确保患者用药安全。

Objective To analyze the causes and characteristics of adverse drug reactions(ADR)in our hospital to provide the basis for clinical rational drug use. Methods 364 cases of ADR report in our hospital from january 1,2012 to December 14,2012 were ret-rospectively and statistically analyzed on the drugs,causal relation evaluation and outcomes according to gender,age,level,administration route,drug category,involved systems / organs and clinical manifestation. Results The ADR occurrence rate caused by intravenous drip was highest(51. 73% );ADR caused by cardiovascular drugs occupied the first place(34. 10% ),followed by the anti - tumor drugs (16. 76% )and anti - microbial drugs(13. 00% );the clinical manifestations were chiefly gastrointestinal lesions(28. 71% );most of pa-tients with ADR could be cured(33. 24% )or improved(56. 94% ). Conclusion Strengthening ADR monitoring and reporting can pro-mote clinical rational drug use and ensure the patient' s medication safety.