摘要
目的研究利伐沙班合成工艺,提高利伐沙班的合成产率,得到适合利伐沙班工业化的合成路线。方法通过查阅文献和专利,筛选出合成各关键中间体最优路线。结果与结论得到一条适用于工业化合成利伐沙班的路线。该法工艺简单,易于分离,适于工业化生产。
Objective To study on the synthesis of rivaroxaban to increase synthesis yield of rivaroxaban and find a route of industrial-ization for the synthetic of rivaroxaban. Methods The key intermediate for synthesis by screening out the optimal route from consulting literature and patents. Results and conclusion A route for the industrial synthesis of rivaroxaban was found. The method has the ad-vantages of simple process, easy separation, and is suitable for industrialized production.
出处
《中国药业》
CAS
2015年第21期4-8,共5页
China Pharmaceuticals
关键词
利伐沙班
中间体
工业化路线
rivaroxaban
intermediates
industrialization route
