早期补充维生素D对早产儿免疫功能的影响

Influence of Early Vitamin D Supplementation on Immune Function of Preterm Infants

目的探讨早产儿早期补充维生素D的临床效果及对其免疫功能的影响。方法将医院新生儿科收治的300例早产儿采用随机数字表法分为对照组和研究组,各150例。对照组给予配方奶粉喂养,研究组在此基础上于出生后第3天开始补充维生素D(500 U/d),连用7 d。结果研究组早产儿试验后血清钙(Ca)、磷(P)、钙磷乘积及25羟维生素D[25-(OH)D]水平分别为(2.24±0.15)mmol/L,(1.23±0.08)mmol/L,(34.34±3.54)和(31.75±3.84)mmol/L,均较治疗前和对照组显著增加(P<0.05);两组免疫球蛋白Ig A,Ig M及Ig G水平与治疗前均略有增加,但差异无统计学意义(P>0.05),且两组间各指标比较也无显著性差异(P>0.05);治疗后对照组白细胞介素-2(IL-2)水平无明显变化(P>0.05),研究组IL-2水平均较治疗前和对照组明显升高(P<0.05)。结论早产儿出生后早期补充维生素D是其健康支持的重要措施,可提高早产儿的免疫力,具有一定的临床应用价值。

Objective To investigate the clinical efficacy and its influence of early vitamin D supplementation on the immune function of preterm infants. Methods 300 cases of premature infants in the hospital were selected and randomly divided into two groups, 150 cases in each group. The control group was given formula fed neonatal while the study group began to received supplement vitamin D (500 U/d ) at 3 d on the basis of the control group, with a continuous treatment of 7 d. Results The calcium, phosphorus, clear Ca × P and 25-( OH ) D levels of premature infants in the study group after the experimental were ( 2. 24 ± 0. 15 ) mmol/L, ( 1. 23 ± 0. 08 ) mmol/L, ( 34. 34 ± 3. 54 ) and ( 31. 75 ± 3. 84 ) mmol/L, which were increased significantly than before the experiment and the control group ( P <0. 05 );the immunoglobulin of IgA, IgM and IgG levels in the premature infants of the study group after the experiment were increased slightly but the difference was not statistically significant ( P > 0. 05 ) when compared with before treatment;the immunoglobulin of IgA, IgM and IgG levels of the control group after the experiment were slightly reduced when compared with before treatment, but the differ-ence was not statistically significant ( P > 0. 05 );there was no significant difference between the two groups on each index ( P > 0. 05 );IL-2 level of the control group had no significant changes after the experiment ( P > 0. 05 ) , while the IL-2 levels in the study group after the experiment were significantly increased than before the experiment and control group ( P < 0. 05 ) . Conclusion Early postnatal supplementation of vitamin D is one of the important measures of health support for the premature infants, which can improve the im-munity of premature infants that has a certain value in clinical application.