甘精胰岛素联合格列美脲治疗2型糖尿病55例

Insulin Glargine Combined with Glimepiride for Treating Type 2 Diabetes in 55 Cases

目的观察甘精胰岛素联合格列美脲治疗2型糖尿病的疗效。方法选取2013年1月至2015年1月门诊收治的2型糖尿病患者110例,随机分为联合组(甘精胰岛素联合格列美脲治疗)和胰岛素组(单用甘精胰岛素),各55例。结果两组患者治疗12周后的空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A1C)显著低于治疗前(P<0.05),联合组治疗12周后的FBG,2 h PG,Hb A1C显著低于胰岛素组(P<0.05);联合组治疗12周后的胰岛素用量显著低于胰岛素组,血糖达标时间显著短于胰岛素组(P<0.05);第0~6周、第7~12周联合组和胰岛素组的低血糖发生率分别为1.82%,0和5.45%,1.82%,均无显著差异(P>0.05)。结论与单用甘精胰岛素相比,甘精胰岛素联合格列美脲能更好地控制2型糖尿病血糖水平,降低胰岛素使用剂量,改善胰岛细胞功能。

Objective To analyze the efficacy of insulin glargine combined with glimepiride in treating type 2 diabetes. Methods 110 cases of patients with type 2 diabetes in the outpatient department from January 2013 to January 2015 were randomly divided into the combination group( insulin glargine combined with glimepiride) and insulin group( insulin glargine only), 55 cases in each group. Results The fasting blood glucose( FBG), postprandial 2 h plasma glucose( 2 h PG), Hb A1 C in the combination group and insulin group after 12 weeks of treatment were significantly lower than before treatment( P < 0. 05). The indexes of FBG,2 h PG,Hb A1 C after 12 weeks of treatment in the combined group were significantly lower than the insulin group( P < 0. 05). The amount of insulin in the combined group after 12 weeks were significantly fewer than in the insulin group,and the time of reaching the standard of blood glucose was significantly shorter than the insulin group( P < 0. 05). The incidence rate of hypoglycemia in 0- 6 weeks and 7- 12 week in the combination group and insulin group were 1. 82%,0 and 5. 45%,1. 82% respectively,showing no significant difference( P >0. 05). Conclusion Compared with using insulin glargine alone, glargine combined with glimepiride has better control of blood sugar levels in type 2 diabetes,decrease the insulin dose and improve the islet cell function.