硝苯地平控释片对氯吡格雷抗血小板功能的影响

Influence of Nifidipine Controlled- Release Tablets on Anti- Platelet Function of Clopidogrel

目的观察合并高血压病的经皮冠状动脉支架植入(PCI)术后患者服用硝苯地平控释片降压对氯吡格雷抗血小板功能的影响。方法将600例合并有高血压病的PCI术后双联抗血小板患者分为治疗组283例和对照组317例,采用比浊法检测血小板最大聚集率(MPAR)。结果治疗组的MPAR显著高于对照组(P<0.01);但随访12个月后,两组患者的不良心脑血管事件(MACCE)发生率比较,差异无统计学意义(P>0.05)。结论硝苯地平控释片可降低氯吡格雷的抗血小板聚集作用,但不增加PCI术后患者的临床MACCE发生率。

Objective To observe the influence of Nifidipine Controlled-Release Tablets(NCT) on the anti-platelet function of Clopi-dogrel on patients who accepted percutaneous coronary intervention(PCI). Methods Totally 600 patients with hypertension who accepted doublet anti-platelet treatment after PCI were divided into the treatment group and the control group. The maximal platelet aggregation rate(MPAR)was examined by turbidimetry method. Results Compared to the non-NCT group,The MPAR of treatment group was sig-nificantly higher than the control group( P < 0. 01);However,the incidence of MACCE was similar between the two groups after one year follow-up( P > 0. 05). Conclusion NCT can decrease the anti-platelet aggregation effect of clopidogrel by laboratory tests,but can't influence the clinical prognosis of patients after PCI.