吸入用布地奈德混悬液对小儿哮喘细胞免疫功能的影响

Influence of Budesonide Suspension for Inhalation on Cellular Immune Function of Pediatric Asthma

目的探讨吸入用布地奈德混悬液治疗小儿哮喘的临床疗效。方法选择医院儿科收治的哮喘患儿84例,按随机数字表法分为治疗组和对照组,各42例。对照组患儿采用常规治疗,治疗组患儿在此基础上加用布地奈德混悬液雾化吸入治疗。结果治疗7 d后,治疗组的咳嗽、气喘、哮鸣音、湿鸣音消失时间均明显短于对照组(P<0.05);治疗组的总有效率为92.86%,显著高于对照组的71.43%(χ2=5.194,P=0.023);治疗后两组患者血清T细胞中CD4+,CD8+,CD4+/CD8+均较治疗前明显降低,且治疗组下降幅度更明显(P<0.05)。结论吸入用布地奈德混悬液可缩短小儿哮喘患者的咳嗽、气喘、哮鸣音、湿鸣音时间,提高临床疗效,调节血清T细胞中CD4+及CD8+的表达,值得临床推广。

Objective To investigate the efficacy of Budesonide Suspension for Inhalation on cellular immune function of pediatric asthma.Methods 84 cases of pediatric asthma patients in the hospital were divided into the treatment group and the control group according to the random number table method,42 cases in each group. The conventional treatment was used in the control group,and the Budesonide Suspension for Inhalation therapy was used in treatment group. Results After treatment,symptoms of cough,asthma,wheezing sound,wet song disappear time of the treatment group were lower than the control group( P < 0. 05). The total effective rate in the treatment group was 92. 86%,which was significantly higher than 71. 43% in the control group( χ2 = 5. 194,P = 0. 023). The serum levels of CD4+,CD8+and CD4+/ CD8+had no difference before treatment; after treatment,CD4+expression increased,CD8+expression decreased,CD4+/ CD8+value reduced,and the differences of CD4+,CD8+and CD4+/ CD8+levels in the treatment group were statistically significant compared with the control group( P < 0. 05). Conclusion The Budesonide Suspension for Inhalation on pediatric asthma can improve pediatric asthma cough,asthma,wheezing sound,wet sound tone,improve the clinical total effective rate,regulate the expression of CD4+and CD8+in T cells,which is worthy of clinical promotion.